vol2 - Page 393

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 I
 which are ve T acute, Those types of changes caused
 2
 by Timolol are those which affect the bronchial--
 ....... 3 the air passages for air to go in and out of the
 4
 lungs_ which occur relatively quickly.
 5
 mean in the majority of those adverse
 6
 effects listed or attEibuted to Timolol_ and they
 undoubtedly are caused by Timolol in the initial
 8
 studies, they were events which occurred relatively
 9 soon after the admlnis_atlon of' the topical drug. I
 10
 mean we _re talking minutes
 ]_ The emphysema-llke changes are these that
 12
 occur over a period of -- a much longer period of
 /_. 13 time_ on a much more chronic basis_
 14" _ Timolol has only be_:n developed for ten
 15
 years. We donor really know yet in a large
 16 population what its iong-ter_ effects on the lungs
 17
 are going to bet do you feel --
 18 E Oh_ that's true, too° _ mean we do notŪ
 _9 _ Okays _mphysema-llke changes_ essentially
 .. 20 the bottom line of that is resulting in making it
 21 difficult to breathe?
 22
 E Un-huh,
 23 _ So in the end the effects of the emphysema-
 24 like changes you claim are caused by marijuana and
 o 25 the effects on the breathing apparatus caused by the
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