vol2 - Page 212

 35. In 1980_ I received a grant from the National Eye
 Institute (NEI) to conduct a study into the lOP lowering
 effects of marijuana and a number of cannabinoids, including
 Delta 9-THC.
 36Q Unlike my earlier study at. Howard Universlty_ ! wast
 through the University of North Carolina's Clinical Research
 Unit, able to conduct longer term in-hospital examination and
 evaluation of patients.
 37. This grant also included extensive lab work on
 various chemicals found in marijuana. Earlier studies
 indicated that a multiplicity of chemicals, many unique to
 marijuanas contributed to the drug's IOP lowering effect.
 Delta 9_TSC, while being the most psycho--active chemical in
 marijuana, is clearly not marijuana's most effective lOP
 lowering chemical.
 38. De!ta-9 T_C pills are not predictably absorbed and
 often illicit dysphoric (panic reaction} side effects in
 elderly marijuana naive subjects°
 39. My first experience with synthetic Delta-9 THC pill_
 .... occurred in November_ 1976_ when _ evaluated Mr. Randall_s lOP
 response to this form of therapy° The pills supplied for
 Mr. Randall were later found to contain less than the stated
 amounts of active Deltas9 THC (most likely due to chemical
 degradation) with age. Mrs Randall had no reduction in !OP
 fo_lowlng his use of synthetic_THC. Marijuanaf however,
 clearly provided Mr. Randall with slgnificant_ long term
 reductions in !OPt