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 episodes and/or the severity of the vomiting which patients
 encountered. If patients could get through their first treat-
 ment without vomiting, they tended to tolerate the therapy
 better during the remainder of their treatment. But finding a
 way to break this cycle was not easy°
 23. During this time I came across reports in the medi˘_i_
 literature =- and in the popular media -_ regarding marijuana_s
 therapeutic value in reducing nausea and vomiting. After dis_
 cussing this information with my superiors at Georgetown
 University, I decided to explore marijuana's possible
 therapeutic application as an anti=emetic adjunct in cancer
 • 24° ! was particularly impressed by the research of a •
 Boston Oncologist_ St,yen Sallano In his study_ Sal!an used
 synthetic THC, a drug derived from marijuana_s most psycho-
 active chemical, Delta-9 T_C. In his report, however, Sallan
 noted some of his younger patients clearly preferred marijuana,
 in smoked forms to the oral THC pi!ls_ Sallan noted there were
 a number of obvious advantages to smoking over oral ingestion.
 25. Through my Georgetown University Fellowship in
 Medical Oncology_ I applied to FDA for _[ND permission to evalu-
 ate marijuana and synthetic THC as anti--emetic drugs.
 26. In dealing with FDA, it quickly became apparent that
 approval for direct research using marijuana cigarettes was
 nearly impossible. In the end, and after twelve months of
 discussion with FDA, I received IND app,:oval, but only to test
 synthetic THC pills°

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