vol1 - Page 346
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able to use marijuana compared to the population using THC_ I_/
Despite these severe restrictions, marijuana was found to be an
effective antiemetic_ In fact, more than half of the physicians
in the program reported marijuana cigarettes to be very or
moderately effective in patients receiving profoundly emetogenic
anticancer_dzn/gs known to induce severe vomiting and nausea° il-q/
The perc_ntage of California patients who discontinued marijuana
therapyfor reasons of side effects was actually lower than in
patients who received oral THC in combination with Compazine (or
other antiemetics), ill/
b. 9/mns_9/_ x
DEA attempts to disregard the importance of Chang's
findings in his 1979 studyo I121/ It is not disputed that
marijuana was found to have significant antiemetic properties in
the context of the Chang/NCX double-blind randomized study. !iI/
DEA first argues that the purpose of the Chang study was to
compare the antiemetic effectiveness of THC to a placebos DEA
omits specifying that the Chang study includes not only oral THC
19__/ ACT Brief at 84_
Ii0/ DEA General Exhibit, Seventeenth Annual Report of the
Research Advisory Panel, 1986, to the Governor & Legislature,
CRAP, San Francisco, 1987, at I0.
...... iii/ /__o at ii.
ii_/ DEA Brief at 31-32o
II// _ Chang, Delta_9oTetrahydrocannabinol as an antiemetic in
Cancer Patients Receiving High-Dose Methotrexate, at 819 in
Affidavit of Dro David Ettinger_ Exhibit 4o
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