vol1 - Page 324
Page 324
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Marijuanas for all its alleged Bvariability_ is a
substance which, when used Win treatments _ produces highly
predictable, reproducible results_ This question was discussed
by the National Cancer Institute as early as 1978. According to
the NCI, marijuana 6 when smoked _ produces "predictable _ _ Wrepro-
N
ducible _herapeutic effects_ In sharp contrasts NCI calls oral
THC_ now a Schedule IX drug (dronabinol) an #erratic n and
_highly unpredictable _ dz_/g. Based on its assessments NCI
determineS, #[A]ll in all the [marijuana_ cigarette is the best
means of delivering the drUgo _42/
On re-directs DEA witness Keitlh Greens PhoD. makes a
...... similar _comparison:
Shirley: [fin your opinion . o o if either
[oral THC] or [smoked marijuana] was . . _ a
viable glaucoma control drug, which form
would be more efficacious in _e treatment of
glaucoma?
Green: I would tend to go with smoking
simply because one has better bio-
availability of the drug. I couldn't go with
the oral [THC] because there is so much
differentiation_tween . . . one patient and
another .... _
According to DEA witness Clarence Fortner_ the California
...... Research Advisory Panel reports similar observations:
In evaluating blood levels following
administration, THC was fothnd to be
erratically absorbed by the oral route.
___/ Affidavit of Robert Randall_ Exhibit 5_ Internal
Memorandum, National Cancer Institutes May 15, 1978, at 1 & 4°
_// Re-direct examination of Keith Green, Ph.D._ Tr° 9-194 & 9 =_
195.
t na [
- 18,-
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