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Department of Ophthalmology at the Unive_ity of North Carolina
at Chapel Hill. 51!/
There were two significant differences between Dr.
Hepler°s earlier investigations and Dr. Merrittas later study.
First, Merritt's study excluded norm0-tensive and ocular
hypertensive persons and was exclusively populated by diseased
patients with abnormally elevated IOP_s and/or a clinical
diagnosis of chronic open-angle glaucoma_ 5-III
Seconds Dr. Merritt_s study included many acute_ short_
term, highly controlled, in-hospital evaluations of marijuana's
effects on the IOP response of glaucoma patients, 51_/ and several
chronic, very long-term evaluations of marijuana's utility as a
mode of therapy_ _/ Dr_ Hepler, as indicated above, seldom con-
ducted acute sh0rt-term evaluations (the majority of his data
...... _ °coming from clinically contained research subjects involved in 34
day and 90 day trials). Hepler also never publicly reported any
data relating to marijuana_s treatment _tility in the long term
management of IOP in glaucomatous patients_
The purpose of Dr. Merritt_s study was not to confirm
Dro Hepler_s earlier findings which were already widely accepted_
but to augment and amplify the available medical knowledge on
511/ Affidavit of Dr. John Merritt_ _ 22-23_ 34_37, 47.
5_12/ /_. at _ 24-26.
__I// /__. at _ 48_53. Dro Merritt outlines the way patients
were evaluated in his University of No_:h Carolina program.
Discussions of controls and procedures.
514/ /__. at 23.
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