vol1 - Page 229

 ®
 Perez-Reyes administered pure cannabinoids to research subjects
 by intravenous infusion to test the acute pharmacological effects
 of these agents on a number of physical systems. One of the
 parameters included in Dr. Perez-Reyesgs study was lOP
 response. _0Q/
 _ Dr° Perez-ReyesSs most striking observation was that a
 nn-her of cannabinoids played a significant role in reducing
 human intraocular tensions. Dr° Perez-Reyes demonstrated that
 while delta-9-Tetrahydrocannabinol (after THC) in isolation could
 significantly reduce intraocular pressures several other
 cannabinoids also had a profound impact on intraocular
 i
 .... _
 pressures.501/
 Significantly, Dr. Perez-Reyes reported that the lOP=
 lowering effects observed on these _alternative cannabinoids n
 equaled or surpassed the lOP declines recorded with synthetic
 delta_9-THC° For example, Dr. Perez-Reyes reports that
 ll-hydroxy-delta_9-Tetrahydrocannabinol and
 delta_8-Tetrahydrocannabinol are extremely effective intraocular
 antihypertensives agents. In fact, delta-8_THC wag superior to
 delta-9-THC in lowering intraocular tensions. Moreover0
 delta-8-THC is far less psychoactive than delta-9-THC.
 Unfortunately, government officials paid little
 attention to the implications of Dr. Perez-Reyeses work.
 i
 500/ ACT Scientific Journal Articles, Exhibit C6_ Perez-Reyes,
 Mario_ nlntravenous Administration of the Cannabinoids and
 Intraocular Pressure, _ Proceedings of the First International
 Conference on the Pharmacology of Cannabis_ Savannah, Georgia,
 December_ 1974o
 5_Q_I/ ___. at 831-832.
 - 156 =