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 smoking marijuana had a base IOP of between I0 and 12 m_ Hg®,
 whereas normal IOP ranges from 12 to 20 _ Hgo In many
 instances_ Shapiro reports self-described marijuana smokers had
 ocular tensions as low as 6 to 8 mm Hg. _9-_/
 Xn Decembers 1974, Dr. Hepler, Dro Frank and Robert
 Petrus_¢anocular tec/%nician) presented a detailed report of their
 latest findings to the First International Conference on the
 Pharmacology of Cannabis, in SavaDmah, Georgia.
 _ Twelve hour observations of 34, subjects were
 made after smoking placebos 1% and 2% natural
 marijuana° Intraocular pressures were
 measured for an initial 5 [hours3 to form a
 stable baseline. After intoxication _ . .
 pressures were measured for another 5
 .... [hours]. There was a consistent drop in
 intraocular pressure, around 30% for 2%
 marijuana, and the reduction appeared to last
 between 4 and 5 [hours 3 .... In
 hospitalized subjects observed for 35 or 94
 days the daily base-line intraocular pressure
 i showed a promptA_9 p as soon as the subjects
 began to smoke. _
 At this same conference, Dr. Mario Perez-Reyes of
 Research Triangle Institute in Chapel Hill, North Carolina,
 presented a detailed analysis of the IOP-lowering properties of
 several cannabinoide including: Delta-9-Tetrahydrocannabinol,
 Delta=8-Tetrahydrocannabinol_ ll-hydro_{_delta-9 _
 Tetrahydrocannabinol, cannabidiol, cannabinol and
 8-Beta-hydroxy-delta_9-Tetrahydrocannabinolo In his study, Dr°
 _5_8/ Id. at 367.
 9_/ ACT Scientific Journal Articles, Exhibit C5, Hepler, Robert
 So, Frank, Ira M. & Petln/s_ Robert, _Oc_llar Effects of Marijuana
 Smoking, w The Pharmacology of Marihuana, edso, M°C. Braude & So
 Szara, Raven Press, New York, 1976_ p.819.
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