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 produced precisely the contrary effect, pupillary
 constrictions 491/
 Pupillary constriction is a common attribute of miotics
 and other drugs used to reduce the elevated intraocu!ar pressures
 (mIOPm) associated with glaucoma. Dro _epler made this
 connection and began evaluating marijuana's effects upon lOP.
 Xn 197i, as noted sumra, Dr. Hepler publicly reported
 his findings to other physicians through the Letters section of
 the Journal of the American Medical Association (NJAMAn):
 The purpose of this letter is to present
 preliminary data concerning the most
 impressive change observed [after subject's
 .... _ smoked marijuana], namely, a substantial
 decrease in intrao_lar pressure observed in
 a large percentage of subjects .... The
 possible implications_ including . o .
 therapeutic action in _$,treatment of
 glaucoma, are obvious. _-_I
 ii As a result of Dr. Hepler_s unexpected findingss the
 UCLA/Marijuana Research Project began a detailed evaluation of
 marijuanats utility as an intraocular antihypertensive agent.
 ..... i The UCLA/Stein analysis of marijuana_s lOP-lowering properties
 continued without interruption from 1970 to 1976. The resulting
 data still constitutes one of the most comprehensive and well
 controlled evaluations of marijuanaSs effects on human
 intraocular pressure.
 _9_i/ ACT Official State Reports, Vol_e If, Exhibit I0, New
 Jersey Glaucoma Protocol at 16_
 492/ ACT Scientific Journal Articles, Exhibit Cl, Hepler, Rober_
 S., & Frank, Ira M. _ nMarijuana Smoking and Intraocular
 .... i Pressurei W 217 J.A.M.A._ 1392 (Sept. 6, 1971) o

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