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produced precisely the contrary effect, pupillary
constrictions 491/
Pupillary constriction is a common attribute of miotics
and other drugs used to reduce the elevated intraocu!ar pressures
(mIOPm) associated with glaucoma. Dro _epler made this
connection and began evaluating marijuana's effects upon lOP.
Xn 197i, as noted sumra, Dr. Hepler publicly reported
his findings to other physicians through the Letters section of
the Journal of the American Medical Association (NJAMAn):
The purpose of this letter is to present
preliminary data concerning the most
impressive change observed [after subject's
.... _ smoked marijuana], namely, a substantial
decrease in intrao_lar pressure observed in
a large percentage of subjects .... The
possible implications_ including . o .
therapeutic action in _$,treatment of
glaucoma, are obvious. _-_I
ii As a result of Dr. Hepler_s unexpected findingss the
UCLA/Marijuana Research Project began a detailed evaluation of
marijuanats utility as an intraocular antihypertensive agent.
..... i The UCLA/Stein analysis of marijuana_s lOP-lowering properties
continued without interruption from 1970 to 1976. The resulting
data still constitutes one of the most comprehensive and well
controlled evaluations of marijuanaSs effects on human
intraocular pressure.
t
_9_i/ ACT Official State Reports, Vol_e If, Exhibit I0, New
Jersey Glaucoma Protocol at 16_
492/ ACT Scientific Journal Articles, Exhibit Cl, Hepler, Rober_
S., & Frank, Ira M. _ nMarijuana Smoking and Intraocular
.... i Pressurei W 217 J.A.M.A._ 1392 (Sept. 6, 1971) o
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