vol1 - Page 216
Page 216
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Ph.D. notes Phospholine lodide_ a miotic drug developed from a
World War XX nerve gas, also causes cataracts. _-Z/
! ........
Timolol recently approved by %_e Food and Drug
Administration as safe in reducing IOP also has adverse side
effects.
More than 3_000 reports of adverse events,
attributed to topical timolol were reported
from September, 1978 through December, 1985
to the Food & Drug Administration . _
Serious adverse respiratory events from
topical beta blockers (FDA-defined) consists
_
of respiratory failure, respiratory distress,
dympnea_ broncho spasm, asthma_ wheezing,
bronchitis, apnea, pulmonary edema,
diminished pulmonary functions and exacer-
bation of preexisting respiratory disease° .
® _ Serious adverse cardiovascular events
...... were defined as follows: cardiac arrests
myocardial infarction, angina_ chest pains
arrhythmia, bradycardia_ tachycardia_
palpitations_ heart failure, cardiospasm,
cerebrovascular accident [stroke]_ syncope,
unspecified cardiovascular di:sorders, and
_+_i exacerbation of preexisting cardiovascular
disease. Reports of hypertension, dizziness,
headache, and hypotension not resulting in
s ope not considered to bo
serlOUSo
Dro John Merritt_ in reviewing timolol°s adverse
effects notes 212 were deemed serious, and resulted in at least
32 confirmed patient deaths. Thirteen of these cases were deemed
cardiovascular deaths; 12 were respiratory deaths; one case was
_67/ Cross-examination of Keith Greene PhoD._ Tr° 9-92_-9_93 &
9-163-164. Dro Merritt provides a graphic illustration of
Phospholline Iodide_s adverse consequences including paralysis_
Merritt Tr. i0_203-204 & 218.
_/ Rebuttal affidavit of Dr° John Merritt, _ 17o
143 -
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