vol1 - Page 209
Page 209
Previous ,
Next ,
Original Image
Return to Index
each drug family. A patient progresses to
the next drug family when a tolerance to the
previous drug develops. Frec_ently, a
..... patient will be prescribed a combination of
dz_/g families in o_ to achieve successful
management of IOP_ _u_
Hepler continues:
> Xt is not unusual for chronic open-angle
:: glaucoma patients to develop tolerances to
all of these conventional medication
families_ Such a tolerance exists when the
medication fails to lower the patientS, IOP
to a safe range, even when the
high_1
:.,_ allowed dosage level has been used. _-_r
Dr. John MeETitt estimated that 25% to 30% of all
glaucoma patients re_aire some form of combination drug
therapy. _-q/
Even aggressive_ combination drug therapies may,
however, prove ineffective in adequately reducing a patient's
intraocular pressure to the so_called _safe u :range [below 20 mm
Hg]. _-I/ Thus the .chemicals currently used in the treatment of
glaucoma may prove inadequate in providing patients with
therapeutically-effective reductions in !OPo Simply stated,
patients may be using all four families of lOP-lowering agents in
combination and at the highest recommended dosages [known as
___/ Affidavit of Robert Randall, Exhibit B, Affidavit of
Robert S. Hepler, April, 1978, at 8o ___ _i__: Cross-
examination of Dr. Richard North, Tro 7-.73. Note: The
introduction of Timoptio_ a beta-blocking drug, into glaucoma
therapy in 1978 has expanded treatment options. Timoptic is now
used as the initial drug of therapy.
_-
4_/ /_. Exhibit B _ 9-10o
__q/ Cross-examination of Dr. John Merritt, Tr ° 10-71
__i/ Affidavit Robert Randall, Exhibit B; Affidavit of
Dr. Robert Hepler, _ 9.
136 -
Previous ,
Next ,
Return to Index