vol1 - Page 206
Page 206
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Dr. Herritt continues:
Blindness is a very grave consequence.
Protecting patients from blindness is
considered so important that it justifies the
use of toxic medicines and uncertain surgical
procedures which in other contexts might be
considered _unsafe m. In practicer physicians
often provide glaucoma patier_s with dr_Aas_
' which have many serious adverse effects_ _/
a. _/la/maco i o_ic_l TheraDie_
_ At presents there are four families of prescriptive
dr_/gs commonly used in the treatment of glaucoma. These include
the miotics, epinephrine compounds, cer1:ain diuretics and topical
beta-blocking drugs°
With the exception of Timolol (commercially known as
Timoptic) _ each of the drags used to treat glaucoma did not
receive NDA approval by FDA prior to marketing. Dr. Richard
North_ a former IND/NDA Clinical Review Officer for ophthalmic
drugs in the Bureau of Drugs, Federal Food and Drug
Administration, 438/ in discussing the drug Diamox _- commonly
used in glaucoma treatments commented:
Diamox is a diuretic ... that was the
approved indication by FDA ® [ Diamox ] was
grandfathered into being used as a pressure-
reducing drug, purely because it was used
outside the normal [FDA-approved] indication
by ophthalmologists.
Stilweil: How did . . . other drugs become
accepted as glaucoma medicine_,?
North: By use as prescribed by the treating
physicians. It would be noted [by
KiZ/ I_, at _I 9-z0.
.....
4_8/ Cross-examination of Dr. Richard North, Tr. 7-62.
- z33 - Of 2 -j3
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