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 nstandardized # the methods by which patients smoked in order to
 nminimize the variation in the a_ount of smoke inhaledo "_2_/
 (b) "' _at
 As suggested above, the New York program involved
 _ several levels of controls. Prior to receiving marijuana within
 the New York programs a cancer patient had to fail to respond to
 one or two types of conventional antismetic therapy. 2_-_/ A
 second round of antiemetic therapy involving synthetic THC pills
 was often given to patients requesting admission into the
 inhalation programo 2_2_/ In effects these restrictions imposed
 severe historical controls on the patients who were finally
 admitted into New York's inhalation marijuana program. These
! historic controls also permit a comparative evaluation of the
 relative utility of conventional antiemetic therapies, synthetic
 THC and marijuanas
 In effect, the New York program set out to determine if
 ...... marijuanas when smoked_ could successfully reduce emesis in
 patients who have failed to respond to conventional agents and
 synthetic THC capsules. This aspect of the New York program is
 /
 cemparable to the Chang/NCI study_s use of marijuana only after
 _21_/ /_o at 7_
 _28/ _o at 4_ (mA history of nausea and vomiting and failure
 of prior antiemetic therapy is required for enrollment in the
 protocol, n )
 _9/ ACT Official State Reports_ Vole XX_ Exhibit 16_ "Annual
 Report to the Governor and Legislature on the Antonio G. Olivieri
 Controlled Substances Therapeutic Research Program, # New York
 State Department of Healths September Is 1982_ at 4.
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