vol1 - Page 121
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marijuana in a randomized, double-blind, placebo controlled
trial. I-_/ The study concluded that both oral THC and smoked
marijuana were effective antiemetics when compared with
placebo. 19_/ However, the study also noted that smoked marijuana
resulted in a lower incidence of nausea and vomiting than oral
THCo Chang demonstrated that #the antiemetic effect of THC is
associated with the THC plasma concentration after oral and
smoked doses_ N,A6_7/ and that #elevations of T_C plasma concen-
• '_ tration were also associated with reductions in the incidence of
nausea and vomiting. #19-_/ In this connection_ the study
demonstrated that the inhalation route achieved higher THC
plasma concentrations than the oral route, and, thus, reached
higher percentages in the reduction of nausea and vomiting in the
patient. 6_/
In discussing the conclusions of the Chang study_ Dr.
Morgan testified that the high rate of success of marijuana in
alleviating the nausea and vomiting had interest for two
reasons"
e
First, it suggests marijuana is an effective
antimemetic drug .... Second, marijuana
achieved this high rate of success in a
patient population that proved unresponsive
19=_/ SeN Chang, D_ita-9-Tetrahvdracannabinol _S _ Antiemetic_._[
Cancer Patie s _ "n Hiqh-Dose MethoL_r_._, at 819 in
Affidavit of Dr. David Ettinger, Exhibit 4.
.....
i___/ __d. The study indicates a statistically significant
benefit from marijuana for vomiting and nausea.. /_d_ at 821.
i__/ ___o at 822°
169/ Id. at 823.
i,
48
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