norml23 - Page 30
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tolerance, dependence, and an abstinence syndrome
strikingly similar to that seen with alcohol and
the barbiturates .... All of the drugs produce
symptoms of intoxication which are similar to one
another and to the barbiturates. Excessive doses
cause varying degrees of drowsiness, confusion, and
motor incoordination with slurred and thick speech,
double vision, staggering and falling. Nemory is
impaired, intellectual functions blunted, and
emotional control reduced° Rage reactions may
occur. Chloral hydrate, a hyposedative introduced
into clinical medicine in 1869, displays certain
characteristic symptoms not observed with other
drugs in this cJass, such as scaling of the eyelids
and scalp, and muscle and joint pains which mimic
arthritis .... With larger doses respiration and
blood pressure are depressed° The patient may
enter a coma which can be fatal. Such deaths have
been reported following overdosage with meprobamate
.... ethcNorvynol and ethimateo
A barbiturateqike dependence pattern develops in
those individuals who abuse these agents° During
periods of chronic intoxication, tolerance and
physical dependence deveiopo Tolerance is usuaJly
correlated with an accelerated hepatic breakdown of
the drug. Ethinamate, however, does not appear to
stimulate liver enzyme activity, but nevertheless
induces tolerance... Abrupt reduction or
discontinuance of dosage precipitates a withdrawaf
syndrome similar to that of barbiturism or
alcoholism .... Ninor symptoms of anxiety,
tremor, insomnia, nausea and vomiting predominate.
Convulsions and deEirium have been reported with
alJ these dependence, which results in withdrawal,
delirium, with prominent paranoia, and occasional
tremor .... As in the case of barbiturates, the
ordeal of abstinence may be life-threatening, and
deaths have occurred during withdrawa_ from
meprobamate ....
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